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Frequently Asked Questions about PREVICOX® (firocoxib)

Fast Relief from the Pain and Inflammation Associated with Arthritis in Dogs¹

PREVICOX is a veterinary-prescription, non-steroidal anti-inflammatory drug (NSAID) used to control pain and inflammation due to dog arthritis—what veterinarians call "canine osteoarthritis." Canine osteoarthritis is a painful condition caused by age, injury, "wear-and-tear" and developmental abnormalities and may result in the following changes or signs in your dog:

  • Limping or lameness.
  • Decreased activity or exercise (reluctance to stand, climb stairs, jump or run, or difficulty in performing normal activities).
  • Stiffness or decreased mobility and flexibility of joints.

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What kind of results can I expect when my dog is treated with PREVICOX for arthritis?
While PREVICOX is not a cure for dog arthritis, it can control the pain and inflammation associated with the disease, which may help improve your dog's mobility.

  • Responses vary from dog to dog, but improvement can be quite dramatic.
  • In most dogs, improvement can be seen within days.
  • If PREVICOX is discontinued or is not given as directed, your dog's pain and inflammation may return.

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Which dogs should not take PREVICOX?
Your dog should not be given PREVICOX if he/she:

  • Has had an allergic reaction to firocoxib, the active ingredient in PREVICOX.
  • Has had an allergic reaction (such as hives, facial swelling, or red or itchy skin) to aspirin or other NSAIDs.
  • Is presently taking aspirin, other NSAIDs, or corticosteroids.
  • Is under 12.5 pounds in body weight.

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What should I tell or ask my veterinarian before giving my dog PREVICOX?
Talk with your veterinarian about:

  • The signs of dog arthritis you have observed in your dog, such as limping or stiffness.
  • The importance of weight control in the management of dog arthritis.
  • What tests might be done before PREVICOX is prescribed.
  • How often your dog may have to be examined by your veterinarian.
  • The risks and benefits of using PREVICOX. Serious adverse reactions, including death, have been associated with PREVICOX administration at doses above the recommended dose in puppies less than seven months of age.

Tell your veterinarian if your dog has ever had one or more of the following medical problems:

  • Any side effects from taking PREVICOX or other NSAIDs, such as aspirin
  • Any digestive upset (vomiting and/or diarrhea)
  • Any kidney disease
  • Any liver disease

Tell your veterinarian about:

  • Any other medical problems or allergies that your dog has now, or has had in the past.
  • All medicines that you are giving or plan to give to your dog, including those you can get without a prescription, and any dietary supplements.
  • Whether your dog is pregnant or nursing, or if you plan to breed your dog.

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How do I give PREVICOX to my dog?
PREVICOX should be given according to your veterinarian's instructions. Do not change the way you give PREVICOX to your dog without first speaking with your veterinarian. Your veterinarian will tell you what amount of PREVICOX is right for your dog and for how long it should be given. Most dogs will take PREVICOX Chewable Tablets from your hand, but you can also place the tablet directly into your dog's mouth. PREVICOX may be given with or without food.

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What are the possible side effects that may occur in my dog during treatment with PREVICOX?
PREVICOX, like other NSAIDS, may cause some side effects. Serious side effects associated with NSAID therapy in dogs can occur with or without warning, and, in rare situations, can result in death. The most common side effects associated with treatment for dog arthritis with PREVICOX involve the digestive tract (vomiting and decreased food consumption). Liver and kidney problems have also been reported with the use of NSAIDs. Look for the following side effects that may indicate your dog is having a problem with PREVICOX, or may have another medical problem in addition to dog arthritis:

  • Decrease or increase in appetite.
  • Vomiting.
  • Change in bowel movements (such as diarrhea, or black, tarry or bloody stools).
  • Change in behavior (such as decreased or increased activity level, lack of coordination, seizure, or aggression).
  • Yellowing of gums, skin, or whites of the eyes (jaundice).
  • Change in drinking habits (frequency or amount consumed).
  • Change in urination habits (frequency, color, or smell).
  • Change in skin (redness, scabs, or scratching).
  • Unexpected weight loss.

It is important to stop treatment and contact your veterinarian immediately if you think your dog has a medical problem or side effect while taking PREVICOX tablets. If you have additional questions about possible side effects, talk with your veterinarian or call 1-877-217-3543.

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Can PREVICOX be given with other medications?
PREVICOX should not be given with other NSAIDs (for example, aspirin, carprofen, etodolac, deracoxib, meloxicam, or tepoxalin) or corticosteroids (for example, prednisone, cortisone, dexamethasone, or triamcinolone). Tell your veterinarian about all medications that you have given your dog in the past, and any medications you are planning to give with PREVICOX tablets. This should include other medicines that you can get without a prescription or any dietary supplements. Your veterinarian may want to check that all of your dog's medicines can be given together.

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What should I do in case my dog consumes more than the prescribed amount of PREVICOX?
Consult your veterinarian immediately if your dog consumes more than the prescribed amount of PREVICOX.

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What else should I know about PREVICOX?

  • As with all prescribed medicines, PREVICOX tablets should be given only to the dog for which they were prescribed. They should be given to your dog only for the condition for which they were prescribed, and at the prescribed dose.
  • It is important to periodically discuss your dog's response to PREVICOX tablets. Your veterinarian will determine if your dog is responding as expected, and if your dog should continue receiving PREVICOX tablets to control the pain of dog arthritis.
  • In the rare case that your dog demonstrates sensitivity to PREVICOX, consult your veterinarian before continuing treatment.

Please ask your veterinarian for more information about PREVICOX® (firocoxib).

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PREVICOX should be given only to dogs.
People should not take PREVICOX. Keep PREVICOX and all medications out of the reach of children. Call your physician immediately if you or a member of your family accidentally takes PREVICOX.

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¹ Hazewinkel HAW, et. al. Comparison of the effects of firocoxib, carprofen and vedaprofen in the sodium urate crystal induced synovitis model of arthritis in dogs. Vet Sci 2008; 84:74-79.

As a class, cyclooxygenase inhibitory NSAIDs may be associated with gastrointestinal, kidney or liver side effects. These are usually mild, but may be serious. Pet owners should discontinue therapy and contact their veterinarian immediately if side effects occur. Evaluation for pre-existing conditions and regular monitoring are recommended for pets on any medication, including PREVICOX. Use with other NSAIDs, corticosteroids or nephrotoxic medication should be avoided. Refer to the prescribing information for complete details.