NSAID Inhibition: COX-1 vs COX-2

Nonsteroidal anti-inflammatory drugs (NSAIDs) exert anti-inflammatory activity by inhibiting 2 forms of the enzyme cyclooxygenase (COX), which have very different functions.8,11

Firocoxib is the most COX-1 sparing inhibitor for dogs, with 0% COX-1 inhibition when COX-2 is inhibited by 80%.8

In this study, minimal COX-1 inhibition occurred at levels consistent with peak plasma levels of firocoxib

Clinical relevance has not been demonstrated